How to Prevent Blisters on Your Feet While Running

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Running Injury
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David Dack

I’ll never forget limping through the last few miles of a half marathon in Bali.

By mile 9, it felt like someone had replaced my sock with a cheese grater. The heat was brutal, my cotton socks were soaked, and by the time I peeled off my shoe at the finish, the heel looked like it went through a meat grinder—bloody and raw.

That day taught me something most runners learn too late: blisters aren’t just annoying—they’re warning shots.

But here’s the good news—blisters can be prevented. Let me show you how.

What’s Really Happening When You Get a Blister

Blisters aren’t random—they’re your skin waving a white flag after too much rubbing and pressure.

Underneath the surface, what’s really going on is your foot bones sliding around while the outer layer of your skin gets stuck to the sock. That pulling force—called “shear”—causes the skin layers to tear apart, and fluid rushes in. Boom—blister.

According to research published in the Journal of Strength & Conditioning Research, these skin injuries are technically “intraepidermal tears caused by repetitive shear deformation.”

That’s the fancy way of saying: rub it enough times, and your foot will fight back.

Now toss in some heat and moisture, and things get worse.

One study showed that when your skin heats up just 4°C, your risk of blistering jumps by 50%. That means sweaty, hot feet (like the ones I had in Bali) are the perfect storm.

It’s all about the friction-moisture-heat triangle. Wet socks let your skin stick and slip at the same time. Heat softens your skin. And bad shoes? They’re the match that lights the fire.

For example, in one ultra-running study, runners who taped their feet saw 98 out of 128 feet stay blister-free. The untaped ones? 81 blistered. That’s not magic—it’s smart prep.

Hot zones to watch:

  • Toes: Too much toe squish or toe-on-toe collisions
  • Heels: Loose heel counter letting your foot slide
  • Ball of the foot: Often caused by stiff shoes that don’t match your push-off style
  • Between the toes? Look into toe socks. Or at least trim your nails tight.

Finding the Right Shoe

Blister-proofing starts with shoes that actually fit your feet—not the ones some influencer said were fast.

Follow the Goldilocks Rule: snug, but not tight. No slipping, no squeezing.

When trying shoes, always wear your real running socks. Laced up, you should have a thumb’s width of space in the toe box so your foot can swell without smashing into the front.

And the midfoot and heel? They should feel locked down without being strangled.

  • Blisters between or on top of your toes? Shoe’s probably too small.
  • Blister on the ball of your foot? Could be too wide there.

What’s more?

Break them in first. Even a great shoe can rub in weird spots until it molds to your foot. I rotate pairs when it’s humid so they can dry out between runs.

And if something feels off in the store—like a pinch or a hot spot—it will come back to haunt you.

Socks Matter More Than You Think

If you’re still running in cotton socks, stop right now. Cotton soaks up sweat, stays wet, and turns into sandpaper inside your shoe.

Instead, go for moisture-wicking socks—synthetic blends or merino wool. You want:

  • Seamless toes
  • A snug fit
  • Light cushioning where it counts

Some of my go-to brands are Balega, Feetures, Smartwool, Darn Tough, and Injinji. Injinji makes toe socks—which I used to hate, but they actually solved my inter-toe blister problems.

And here’s a sneaky trick: use thin liner socks under your main pair. A study on US Marines found that this combo (polyester liner + normal sock) cut down both the number and size of blisters. The liner and sock rub against each other, not your skin.

A few more running sock rules from the trenches:

  • No cotton. Ever.
  • Look for socks labeled “moisture-wicking” or “technical”
  • Merino wool works in all seasons—keeps feet dry and stank-free
  • On rainy or muddy days, carry a backup pair
  • Check for bunching, especially under calluses

I’ve even doubled up on long races—thin Injinji toe liners inside a snug outer sock. Feels weird at first, but worth it when your feet survive 30+ kilometers without a single blister.

My Pre-Run Ritual to Keep Blisters Away

Before every long run or race, I treat my feet like they’re the engine of the whole operation—because they are. I’ve bled through socks enough times to know that skipping foot prep is a rookie move.

Here’s what works for me:

Grease up the danger zones

First step: lube. I rub BodyGlide—or just plain old Vaseline—on every hotspot I’ve learned the hard way to respect: backs of the heels, balls of the feet, under my big toes. One study showed that petroleum jelly actually reduced friction better than anything else tested.

It’s not some miracle—just smart prevention. Sometimes I’ll even stop mid-run to reapply if I feel a hot spot heating up.

Powder is your best friend on humid days

When Bali heat is cranked up, I toss some talcum powder between my toes and on the arches. According to the same research, powder outperformed antiperspirant at keeping skin dry and blister-free.

It sucks up sweat and puts a light barrier between skin and sock. If you’re going the antiperspirant route, hit your feet a night or two before race day—gives it time to work in.

Tape like a pro

I used to hate tape. Now I don’t leave home without it. Taping the right spots—your heels, inner toes, or wherever trouble starts—can cut your blister risk way down.

I use KT Tape or moleskin strips on training days. On race day, I carry Leukotape in case I need an emergency fix. It’s sticky as hell, but if a blister starts forming, I’ll stop, wrap it up, and keep going.

That one-minute stop saves me from limping the next 10K.

Keep skin soft—until race day

Cracked, hard skin is blister bait. I exfoliate and moisturize my feet nightly—especially after trail runs—to keep calluses smooth and even. When they get jagged or too thick, they tend to peel mid-run.

But I skip moisturizing on race day. I want just enough grip, not slick soles.

Test your setup

Trying a new sock? New anti-blister cream? Don’t wing it on race day. I always test things out on a shorter 5–10K run.

One time I forgot to rinse off BodyGlide and nearly face-planted on the treadmill from slipping so much. Lesson learned—real-world testing is mandatory before you commit to anything for 20 miles.

Lacing Tricks That Save Your Skin

Believe it or not, your laces could be causing your blisters. Here’s how I tie smart, not tight:

The Heel-Lock Loop

This one’s saved my heels on many runs. It locks your foot down so there’s no up-and-down rub.

ASICS explains that a proper heel-lock can stop excessive movement and lower friction risk. I use it on any run over 10K. Just loop the laces through the top eyelet on the same side to make two loops, then cross them through each other before tying.

If my heel still lifts, I tighten those loops or grab a different shoe with more ankle support. REI backs this trick too (source).

Parallel Lacing (a.k.a. “window lacing”)

If your shoes dig into the top of your foot or crush a bunion, this method’s a game-changer.

Just skip every other eyelet so the laces lie straight instead of crisscrossing. This can take pressure off sore spots. For a high toe box or bruised toenail, you can leave a small “window” in the lacing to give that area more breathing room.

Tiny tweaks here can make a huge difference on a long run.

BOA or Quick-Lace Systems

On trails, I sometimes go with shoes that have BOA dials or speed-laces. One click, and you’ve got even pressure without fuss.

I don’t have a study to throw at you, but after running a few ultras, I’ll say this: being able to tighten or loosen on the fly is gold—especially mid-race when your feet start swelling.

Pro tip: If your laces feel weird mid-run, stop and fix them. Don’t push through. One knot in the wrong spot can sideline you for weeks.

When Weather Goes Full Savage

Hot. Wet. Muddy. Sandy. These are the days when your usual routine isn’t enough.

Here’s how I fight back:

Block the grit

A single grain of sand in your sock can ruin your race.

I never head into muddy trails or sand dunes without gaiters. These wrap around the top of your shoe and stop junk from sneaking in. One blister guide recommends them for any terrain that’s messy.

I’ve worn gaiters through flash-flood trail runs—they kept the mayhem out and my feet running smooth.

Change socks—often

In ultras, I swap socks every 20 to 30K or whenever they get soaked.

Wet socks = blisters waiting to happen.

I stash backups at aid stations, or even wrap them in a Ziploc in my pack. Ultra coaches hammer this point home: once your feet hit “maceration mode”—all pruney and paper-thin—you’re done.

Change early. Change often.

Pre-treat like it’s race day

If I know the race is going to be sweltering, I hit my feet with antiperspirant or cornstarch powder a day or two before. It helps slow the sweat.

On race day? It’s all about powder and a prayer.

One study comparing powders to sprays found that powder kept feet drier and helped avoid blisters better.

Dry out your gear

After long runs, I’ll pull the insoles out of my shoes and sun-dry everything. No moisture = fewer problems.

In brutal humidity, I’ll even wear liner socks made from moisture-wicking material. They’re thin, but they stop that awful soggy sock feel you get with cotton.

Blister Treatment: When It’s Too Late to Prevent

Let’s be honest—sometimes, no matter how careful you are, a blister sneaks in like a ninja.

When that happens, here’s how to deal without wrecking your run:

Don’t Just Pop It

I know the urge.

You spot that bubble on your foot and just want to stab it. But hold up—most experts  warn against popping blisters right away.

That fluid-filled roof? It’s actually your body’s natural bandage, protecting the raw skin underneath.

If the blister’s small and doesn’t hurt like hell, just leave it. Slap on a clean bandage or some moleskin, and keep pressure off it.

Do NOT peel the top off, even if it looks ugly. That’s a shortcut to infection city.

If You Have to Pop It…

Now, if you’ve got a big ol’ painful one and every step feels like you’re landing on a thumbtack, okay—drain it the smart way.

Here’s how I’ve done it on the trail:

  1. Clean your hands and the blister with antiseptic.
  2. Heat up a sewing needle or pin in a flame, let it cool, and gently poke the edge—just enough to let the fluid out.
  3. Press from the opposite side to drain most of the gunk. Keep the roof (top skin) intact.
  4. Add antibiotic ointment and cover it with a donut-shaped moleskin pad or a real blister bandage.

That “donut” shape? It keeps pressure off the sore spot.

One foot care expert on Healthline even says surrounding the blister with padding cuts down friction. And from experience?

That one move can make the difference between finishing a race or hobbling home.

Aftercare Matters

No matter if you drained it or not—keep it clean and dry.

Change the bandage daily. If it was popped, apply antiseptic every time.

Watch for signs of infection—redness spreading, worsening pain, or pus. If you see any of that, hit up a doc—especially if you’ve got diabetes or poor circulation.

Foot stuff can escalate quick if ignored. Trust me, I’ve seen it.

Special Note for Diabetics

If you’ve got diabetes, this isn’t DIY territory.

Blisters can hide deeper wounds. Don’t try to tough it out—go see a doctor before it turns serious.

Bottom line? A blister isn’t “just” a blister. Treat it like an injury. Clean it. Protect it. Let it heal. You might even be able to run on it—with padding—without ending up with a DNF.

Crowd-Sourced Blister Hacks 

Blister prevention has almost a cult following online. I’ve dug through forums, coaching chats, and heard some wild tricks over the years—some smart, some borderline insane.

Here’s what’s stuck with me (and yep, I’ve tried most of these):

Anti-Chafe Staples?!

An ultra-runner once told me she literally stapled gauze to her heels before a desert ultra.

Yep—staples.

I’m not saying go full Rambo, but it shows how desperate we get. Personally, I stick with duct tape or Leukotape. They’re rugged, stay put, and won’t draw blood.

Wax or Oil

Some folks swear by beeswax or a dab of coconut oil on friction spots. It’s supposed to create a slick surface inside the shoe. I tried coconut oil once. Slid around like I was ice skating in my socks. These days I go with BodyGlide—less mess, more control.

Latex Gloves Hack

This one’s common among ultrarunners in nasty weather:

Wear latex or nitrile gloves under your socks. It works like a waterproof liner.

Yeah, they get hot, but if you’re sloshing through rivers or racing in monsoon conditions, they keep your feet drier than you’d think.

Moleskin on Every Toe

Time-consuming? Absolutely. But if your blisters show up between the toes, wrapping each one in moleskin is magic.

I’ve coached runners who swear by it for ultras and marathons.

Inside-Out Socks

This one’s subtle—some runners flip their wicking socks inside-out.
Why? The smoother side goes against your foot, reducing rubbing from the stitching.

I was skeptical too, but it’s helped on long trail runs.

💡 Moral of the story? Experiment. Mix and match. Find what works before race day—and never try a new hack during the actual event.

Your Pre-Run Blister Checklist (Save This)

This is the quick and dirty foot-check I walk clients through before any big run:

  • Shoe Fit Check. One thumb’s length of space up front, snug heel, and zero toe numbness.
  • Sock Audit. Say no to cotton. Stick with moisture-wicking socks or a liner + outer combo. No bunching allowed.
  • Lube the Hotspots. Think heel, toes, and ball of foot. BodyGlide, Vaseline—whatever works for you.
  • Tape Early. Know your danger zones? Pre-tape them. If something feels off during warm-up, don’t wait.
  • Weather Plan. Rain in the forecast? Pack gaiters and dry socks.
    Hot out? Bring foot powder or antiperspirant.
  • Race Kit. Include a mini blister kit: moleskin, bandages, lube, safety pin/needle, powder.
  • Bonus tip: Stick a square of duct tape inside your singlet. You never know.

Final Thoughts: Respect Your Feet

Here’s the deal—you can’t race well if your feet are wrecked.

I tell every runner I coach: your feet are the foundation. Doesn’t matter if you’re running Bali trails or city marathons—if your base is broken, everything falls apart.

So make blister prevention part of your regular prep. Not an afterthought.

And now it’s your turn—what’s your go-to trick?
Drop it in the comments. Share it with your running crew. Let’s keep each other moving, not limping.

Happy running—and keep those toes blister-free. 

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